![]() Tamm ER, Lutjen-Drecoll E (1996) Ciliary body. Arch Ophthalmol 100:1942–1947Ĭvekl A, Ashery-Padan R (2014) The cellular and molecular mechanisms of vertebrate lens development. Johnson DH, Bourne WM, Campbell RJ (1982) The ultrastructure of Descemet’s membrane. Vis Res 10:107–108īoote C, Dennis S, Newton RH, Puri H, Meek KM (2003) Collagen fibrils appear more closely packed in the prepupillary cornea: optical and biomechanical implications. Maurice DM (1970) The transparency of the corneal stroma. Mosby Elsevier/Elsevier Inc., Edinburgh, pp 203–208 In: Yanoff M, Duker JS (eds) Ophthalmology, 3rd edn. Sinauer Associates, Inc, Sunderland, pp 411–445, 708–732įarjo AA, McDermott ML, Soong HK (2009) Corneal anatomy, physiology, and wound healing. Oyster CW (1999) The human eye: structure and function. Warwick R, Williams PL (eds) (1973) Gray’s anatomy, 35th British edition. Academic Press, Orlando, pp 1–64īorn AJ, Tripathi RC, Tripathi BJ (1997) Wolff’s anatomy of the eye and orbit, 8th edn. Stimulated by retinoic acid 6 protein TGF-β:ĭavson H (1984) The eye, vol 1a. Lens epithelium-derived growth factor LGN: Intracellular retinol-binding protein IS: Α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid bb:Ĭellular retinaldehyde-binding protein CRBP: We will next provide morphological and functional details concerning the various cell types that comprise the many layers of the retina, and we will conclude by describing the series of reactions that constitute the visual retinoid cycle and the various key proteins that facilitate it. Thus, this chapter will provide a general overview that begins with the gross anatomical features of the human eye followed by a description of the histology of the mammalian retina. The purpose of this chapter is to help facilitate a thorough understanding of the subsequent chapters of this volume that focus on key ophthalmic diseases, recent developments in drug discovery efforts toward treating these diseases, and the challenges faced in the delivery of drugs to their ocular targets. In this chapter, we will provide basic background information of the human eye and retina required for readers unfamiliar with the field of ophthalmic drug discovery. Irreversible blindness affects nearly 60 million individuals worldwide, with the leading causes including age-related macular degeneration, glaucoma, and retinal vascular disease. Loss of visual acuity or blindness presents a significant negative impact on quality of life. There, the neural signal is processed to give rise to color differentiation, brightness perception, contrast, and depth perception. This remarkable organ is capable of phototransduction, which involves the conversion of photon energy into an integrated neural signal that propagates through the optic nerve as an action potential to the visual cortex of the brain. Its intricate and complex anatomy has evolved to effectively focus incoming light from the surrounding environment and to harness its energy by efficiently utilizing the physicochemical properties of retinoids. ![]() The human eye is a part of the sensory nervous system and is the organ responsible for conscious light perception and vision.
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![]() These are some of the best STEM careers to get into. Others require graduate-level education with skills and experience to match. Some STEM careers require no college degree. STEM careers cover a wide array of disciplines, careers, industries, and requirements. STEM stands for science, technology, engineering and mathematics. Get started with ziprecruiter What Are STEM Careers? You can also upload your resume to ZipRecruiter’s resume database so that recruiters and employers can reach out to you! ZipRecruiter is free for job seekers and you can easily apply for jobs with a single click. ![]() If you want to land a STEM career, start your job search on ZipRecruiter. Our team has researched the best resume writing services to help you out. Investing some money to have a resume writing service help with your resume can be the edge you need. Think about it like this: you’re selling the company on a major investment in you, so you need to do everything you can to get an edge. You’ll learn more about what STEM careers are all about and we’ll share 20 of the best STEM careers including: In this article, we’re going to cover the best STEM careers to consider this year. There are also many diverse industries you can work in like healthcare, business, tech, and more. You’ll be challenged in your work and be introduced to new technologies that are discovered. This is a great career field to be in for people who want to work in science and technology-related jobs. Working in STEM can also bring lots of opportunities for career development and growth, benefits, flexible work options, and other perks. It’s also fast-growing, expected to grow by 7.7% by 2030. STEM careers are one of the highest paying on the job market. ![]() ![]() Moreover, Mitti offers MIDI and OSC control, allowing users to integrate the software with external controllers and equipment for seamless live operation. Users can adjust playback settings, apply effects, and synchronize video with audio, making it easy to create captivating visual sequences. ![]() The software includes a comprehensive timeline editor that enables users to fine-tune their video cues with precision. This feature is particularly valuable for synchronized presentations, live performances, and multimedia shows. Users can create and organize video cues, ensuring that each clip is played at the right moment during the event. Mitti excels in its ability to provide cue-based video playback. The drag-and-drop functionality and keyboard shortcuts further enhance the user experience, allowing for quick and precise cueing of video clips. Whether you’re a seasoned professional or a newcomer to live events, the organized layout and straightforward controls of Mitti make it accessible and efficient. The software offers an intuitive and user-friendly interface that streamlines the video playback process. This versatility allows users to seamlessly integrate video content into their live performances, enhancing the overall visual experience. The software supports a wide range of video formats, resolutions, and codecs, ensuring compatibility with various media sources and hardware setups. One of the standout features of Mitti is its ability to provide users with flexible and reliable video playback. It stands out as an essential tool for anyone involved in live events, whether it’s a theatrical performance, music concert, conference, or nightclub show. This robust application serves as a comprehensive tool for video playback and control, catering to the diverse needs of event organizers, DJs, VJs, and anyone seeking to enhance their live visual experiences.Īt its core, Mitti functions as a professional-grade video playback and cueing software, tailored exclusively for macOS. Mitti is a versatile and powerful macOS software designed for professionals in the world of live events, performances, and presentations. Mitti is a modern, feature-packed but easy-to-use pro video cue playback solution for theatre, audiovisual shows, performances, and exhibitions. Download Mitti 2 for Mac full version program free setup. Yet judges still appear to be treating the form as some fresh, inexplicable phenomenon. ![]() Early rap is to 2023 as Tommy Dorsey and Glenn Miller were to 1983. Grandmaster Flash, whose single The Message kicked open the doors, has somehow reached the age of 65. It is just over 40 years since the music went properly mainstream. It is half a century since hip hop germinated in the Bronx. A genre of urban popular music that involves the delivery of spoken lyrics over an electronic beat.” What to listen for on Dr.“Rap, your honour. Dre and Ice Cube relive youth on 'Straight Outta Compton' set 2005's "Get Rich or Die Tryin'," 50 Cent's attempt at an "8 Mile"-like autobiography and 2006's "ATL," which looked at the early days of the Atlanta scene (inspired by the lives of producer Dallas Austin and TLC's T-Boz), and featured T.I., OutKast's Big Boi and others.ĭr. More recent efforts include 2009's "Notorious," centered on the rise and fall of Notorious B.I.G. "Krush Groove," a fictionalized look at the inception of Russell Simmons and Rick Rubin's Def Jam Recordings featuring Run-D.M.C., the Beastie Boys and LL Cool J, pioneered the subgenre in 1985. Biopics focusing on hip-hop stars have had an inconsistent track record, with 2002's "8 Mile" - an autobiographical look at Eminem's early days in Detroit - receiving the most critical and commercial success. "Straight Outta Compton" is the most recent in a slew of music biographies, following 2014's "Get On Up" (James Brown) and "Jimi: All Is By My Side" (Jimi Hendrix) and this year's "Love and Mercy" (Brian Wilson). See also: “Scarface,” “Goodfellas,” “New Jack City,” “Juice,” “Carlito’s Way,” “American Gangster,” et al. "Menace" marked the directorial debut of the Hughes Brothers, who later helmed "From Hell" and "The Book of Eli." Rumor has it that N.W.A's MC Ren was considered for the supporting role of A-Wax but turned it down (the role instead went to fellow Compton rapper MC Eiht). Indicting the cyclical nature of violence in an area where opportunities are limited, the bleak "Menace" gives Caine a glimpse of a better future, only to have it taken away as his past sins come back to haunt him. "Menace" finds impressionable South Central teenager Caine (Tyrin Turner) falling into a life of increasingly reckless crime along with his memorably menacing pal, O-Dog (Larenz Tate). While "Boyz n the Hood" allowed a ray of hope for at least one of its three main protagonists, the angry "Menace" stepped up the violence and tragedy quotient in the manner of earlier gangster films. Here’s some recommended additional viewing for moviegoers headed to "Straight Outta Compton" this weekend. The group's debut album arrived just as a new wave of black filmmakers - influenced by hip-hop culture as much as cinema history - began depicting similar stories and characters in their films.įull coverage: 'Straight Outta Compton' and N.W.A's legacy Dre and Ice Cube - is the first film to dramatize the group's controversial ascension, but N.W.A's angry message had found its way onto the big screen in a variety of different ways much earlier. "Straight Outta Compton" - produced by Dr. Films like "Boyz n the Hood" or "Menace II Society" probably wouldn't have been made without the late-'80s success of N.W.A and like-minded musical acts, who were expressing the frustrations of inner-city life by discussing poverty, drugs, gang violence and police brutality. With no-holds-barred lyrics, rapid-fire rhymes and explosive, hard-hitting beats, the quintet (Cube exited after their debut album) not only influenced a generation of hip-hop artists but also helped bring underrepresented black voices to the mainstream and into the multiplex. Dre, Ice Cube, Eazy-E, MC Ren and DJ Yella. ![]() Gary Gray-directed "Straight Outta Compton" chronicles the brief but influential existence of pioneering L.A. Have a look at my notes on one of the secondary sources: This, of course, takes time, but once one starts linking the pages within the app, magic starts to happen. Here is an example of how my page on Chinese history looks like, with subpages according to ruling dynasties, where I write whatever I feel is important to remember. They are not particularly organized or exhaustive (Sinologists will surely notice the missing lines in the list below), but they grow steadily and get better with time. This collection is much more chaotic and has notes on any possible topics I am interested in, including programming tips, instructions on how to write a cover letter and, of course, all the notes on China I feel are important to preserve. The second type of entries I have is a wiki: that is, a collection of notes arranged by topic rather than the source. Each entry is associated with a Notion subpage that has my short summary of a book or an article. The table below shows a similar table I keep in English: here too I chose to mark authors, topics, and types of materials. The picture below is a snapshot of a table I created for primary sources I am interested in: for each page with notes I did about a source text I chose to add columns with information on authors and editors, a rough period of creation, and tags that in most cases reflect the genre of the primary source. These databases are essentially tables that contain links to user-created pages filled with notes, and columns with additional information and tags that allow sorting and filtering. The first one is several databases with notes for source books, secondary literature, historical figures and terminology. There are two main parts to the system I created. In this post, I will give a short guide to it in case you find it useful for your own work. The most important part of it all was creating and maintaining my personal knowledge base that contains notes on all things I find useful for my research. To give you an idea of how heavily I rely on it, see the screenshot of the list of most used pages in my account: Notion is a multitool that can turn into a to-do list, a kanban board, a database, and even a personal webpage – all of which can be quite intimidating.Īnd yet, I have abandoned every single other app and keep sticking to this one: I manage several projects with multiple participants in it I use it for tracking bugs in my code to write down first drafts of my papers or again to manage courses I teach, etc. There is, of course, a certain learning curve involved, and one has to gain familiarity with the design choices made by the developers. ![]() ![]() Notion is an app that offers extremely flexible organization of user content, which can in most cases be achieved by dragging and dropping things around. Our hopes to exhaust all learning within one lifetime are long gone – and are replaced by the hopes to at least manage knowledge related to a single domain.Įvery person has a different system to do so – as demonstrated in many of the previous posts in Digital Orientalist – and I have created mine with the help of Notion. ![]() Since then, we have lost many but produced incomparably more texts. A person raises a foot and walks down the road of learning, and yet, even when one’s hair turns white, one will not have exhausted everything” complained a sixth-century Chinese prince Xiao Yi 蕭繹 about having too many texts to read as he was compiling the Jinlouzi 金樓子 treatise (Tian, 132). The texts of old pile up high, with more texts being produced ceaselessly. “Nowadays, each family produces writings, and every person has a collection. ![]() Secure access in a permissioned blockchain is protected by Oracle Identity Cloud Service with behavioral authentication, single sign-on, and key management services. Deliver Business Results-with the ability to rapidly onboard and easily scale global network participants, your operations run continually with resilience, high availability, and autonomous recoverability.This enterprise-grade blockchain solution will enable us and our customers to: We believe this technology platform can be a significant revenue generator for the company as healthcare professionals such physicians, medical facilities including the nursing homes we currently service will be able to utilize the subscription service that will use a multi-signature, multi-layer secure key code through a set of customized nodes to transport data.”Īs blockchain technology continues to evolve, Oracle will stay on top of the latest capabilities to ensure that our technology stays agile and competitive.īernard continued, “With Oracle’s collaboration with development and their Blockchain Cloud Service, we can accelerate revenue, create new revenue streams, and reduce cost and risk by securely extending medical blockchain business applications and processes while speeding up transactions across our partner ecosystem.” Ricky Bernard, President of Quantum Medical, commented: “QuantH Medical Blockchain Technology will enable secure encryption data sharing (Health Information Data Exchange) that will be HIPAA compliant. Quantum Medical Transport, Inc.’s (OTC PINK: DRWN) QuantH is currently being developed on Oracle’s cloud-based integration platform, where, QuantH Medical Blockchain Technology will enable secure encryption data sharing (Health Information Data Exchange), on a Hyperfabric Ledger Linux Platform. In response, Oracle’s head of blockchain technology invited Quantum Medical to participate in the Oracle’s Blockchain Cloud Platform Beta Program in support of developing the Company’s QuantH medical blockchain technology. Ricky Bernard, President of Quantum Medical, reached out to Oracle Corporation for a joint development of Quantum’s QuantH medical blockchain technology. Oracle Corporation’s cloud-based integration platform is the largest provider to banks and supply chain vendors for the transfer of information and can handle the large amounts of data that the transmittal of medical practices require. Quantum Medical Transport, Inc.’s (OTC PINK: DRWN) QuantH, its own proprietary medical blockchain technology, is currently in development and will launch as the first HIPAA (Health Insurance Portability and Accountability Act) compliant blockchain technology. (OTC PINK: DRWN), an emerging growth medical services company (the “Company”) announces its acceptance of Oracle Corp’s invitation to participate in the Oracle Blockchain Cloud Platform Beta program, as the first step in developing “QuantH”, a HIPAA compliant medical blockchain technology.
![]() ![]() Sign in with your Apple ID at for free, then try the above steps again.Look for iOS 17.3 Developer Beta to appear, choose Download and Install.A paid Apple Developer account is no longer needed – but you may need to sign in with your Apple ID at if you haven’t before.(If not, you’ll need to update before getting the in-Settings beta option.) Perform live with 100 instrument, effect and MIDI plug-ins or work with Audio Units plug-ins. Double check you’re running iOS 16.4 or later. MainStage lets you take your Mac to the stage with a full-screen interface optimised for live performance, flexible hardware control and a massive collection of plug-ins and sounds that are fully compatible with Logic Pro. ![]() Try quitting and relaunching the Settings app.If you’re not seeing the option to turn on beta updates or iOS 17.3 appear: Look for iOS 17.3 Public Beta to appear choose Download and Install.If you need to change your Apple ID associated with the beta, you can tap that at the bottom.Choose the new Beta Updates button (it may take a moment to appear).Launch the Settings app on your iPhone or iPad (running at least iOS 16.4).They will be able to give you a more accurate timeline for when it is safe to update. We also ask that you check in with the manufacturers of the software you use (ex. You may need to sign in with your Apple ID at if you haven’t before. If you must update to Big Sur or to MainStage 3.5, make sure to run a full backup of your system before proceeding.Make a fresh backup of your iPhone or iPad.Swipe down and tap Face ID & Passcode (or Touch ID & Passcode).Apple launches Stolen Device Protection for iPhone with iOS 17.3 beta, here’s how it worksĪfter you follow the steps below to install the free iOS 17.3 public or dev beta, you’ll be able to:.It adds a layer of security for your Apple ID and more in the rare event your iPhone is stolen and your device passcode is also compromised. The major new feature to arrive with the test software is Stolen Device Protection for iPhone. Want to try out the latest iPhone security feature – Stolen Device Protection for iPhone? Read along for how to install iOS 17.3 beta for free, as well as where to turn on the new iPhone protection that requires biometric authentication and more.Īpple has made the first iOS 17.3 beta available for both public and developer testers. This is the wrong time of the year, though, to be leaving cold items in the back seat or trunk of the car, even for just a few minutes. And guess what? We do that frugal thing, where we go to one store for some items, and then head down the road for a few other items, because they're less expensive. Oh yes- it's always something that needs to be kept refrigerated. Why? It's simply too hot to even want to go outside! Dragging items back and forth between the car and the house just seems icky! If I have to grocery shop during the week, it's usually because we're out of a staple, like milk, eggs, coffee creamer, sour cream. –> summer in full swing, I almost dread going grocery shopping. Make sure to join my VIP customer group for games, giveaways, and fun. ![]() If you still have questions about Thirty-One Utility Totes, I’m here to answer them! Leave a comment on this article or message me here. If you’re ready to go shopping, you can visit. View available patterns –> Tiny Utility Tote ![]() Your kids will love having their own travel tote to take their belongings along on car trips, Grandma’s house, or the playground. Use it as a handy bathroom caddy, pantry organizer, storage container, or even as a great reusable gift bag for birthdays, holidays, and other special occasions. The miniature version of our best-selling Large Utility Tote, the Tiny Utility Tote has all the same features, but on a smaller scale. Read 31 Uses For Your Small Utility Tote Tiny Utility Tote View available patterns –> Small Utility Tote Put it in the closet to hold hats and gloves.ġ1.75″H x 11.75″L x 9″W with a 14′ handle drop.Pack it with emergency supplies and keep it in your trunk.Keep in the kiddos room for action figures, art supplies, or books.It’s also the perfect size for keeping things organized at home or while you’re away. View available patterns here –> Zip-Top Organizing Utility Tote Small Utility Toteĭon’t be fooled by the Small Utility Tote – it may be small but it’s mighty! Just under a foot tall and wide, it fits easily into smaller spaces and on your closet, pantry, and garage shelves. Featuring seven total exterior pockets, including two side mesh pockets, it carries loads up to 25 pounds.Īpprox. This versatile bag was made to go where you go use it as a diaper bag when you’re out and about with the baby or organize your car, basement, closets, laundry room, or craft supplies at home. The Zip-Top Organizing Utility Tote (ZOUT) is the only utility tote style to feature a zipper closure to keep all of your items safe and secure. This Customer-favorite style only comes out once or twice each year. The Medium Utility Tote has all the features of its big sister (Large Utility Tote) but is just the right size for toys, video games, mismatched socks, or loose items in the car.ġ0″H x 18″L x 9″D. Read 31 Uses For Your Large Utility Tote Medium Utility Tote View available patterns here –> Large Utility Totes This big tote also makes the perfect storage bin or closet organizer for just about anything around the house, including toys, books, blankets, laundry, tools, seasonal clothing or shoes, holiday decorations, car care items, and more.Ĭapable of carrying loads up to 50 pounds, it also collapses flat for easy storage.ġ1.75″H x 21.5″L x 10″W with 14.5″ handle drop. The Large Utility Tote makes a great camping tote, sports equipment bag, picnic basket, beach bag, pool tote, or reusable grocery bag. That’s 12+ years of hauling, storing, schlepping, carrying, and moving whatever you throw in it. Often imitated but never duplicated, the Large Utility Tote has been a bestseller since its debut in 2009. View available patterns –> Deluxe Utility Tote Large Utility Tote There are also three exterior pockets for additional storage.ġ1.75″H x 21.5″L x 12.625″W with 15″ handle drop. Ī hard bottom gives it more stability than our other totes, while top and side webbed handles offer additional strength for loads up to 60 pounds. ![]() A slightly bigger and sturdier version of the Large Utility Tote, the extra storage capacity allows this tote to hold heavy groceries, cleaning supplies, or laundry. Kicking things off we have the Granddaddy of our tote collection, the Deluxe Utility Tote. Metal grommets: Provides protection against everyday wear and tear. ![]()
![]() Chief Architect: Excellent Home Design Software.3D Studio Max: Great for Full Visualizations.SketchUp: Best Free Architecture Software.ArchiCAD: Good Architecture Software for Beginners.Rhino 3D: Best 3D Architecture Software. ![]() Top Picks Best Architecture Software – Full Round-Up We’ll also discuss how to use these tools to step beyond concept drawings and exterior models to design interiors and populate buildings with 3D modeling. In this guide, I’ll compare my favorite tools across key characteristics like functionality, ease of use, platform compatibility, and price so you can decide which is right for you. It’s the industry standard, with specific architectural toolsets including pre-built objects like doors and windows to speed up the drawing process. If you’re looking to produce 2D architectural plans, AutoCad is the best choice. It has a steep learning curve, but once mastered, it provides a competitive edge for BIM-focused 3D modeling, with automation tools that improve efficiency and intuitive collaboration features. While each has its strengths, it’s crucial to choose one that suits your project and skill level best to get the most from these tools.įor most users, the best 3D architecture software is Revit. Over the past couple of years, I’ve tested plenty of powerful drawing and modeling tools. Using the best 3D architecture software will help take the stress out of visualizing, creating, and rendering building designs. |
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